Cerenis Therapeutics

Management

Jean-Louis Dasseux, Ph.D., M.B.A.

Founder and CEO, Cerenis Therapeutics

Dr. Jean-Louis Dasseux is the founder of Cerenis and one of the world’s leading experts in lipid metabolism, lipid-protein interaction, and cardiovascular disease. He has more than 25 years of experience in the pharmaceutical industry. Dr. Dasseux has generated more than 60 patents related to HDL, RLT, and the treatment of cardiovascular disease. He was the inventor of a high-capacity reverse lipid transport peptide HDL mimetic (ETC-642) and a series of small molecule compounds that raise HDL levels (ETC-1001 and ETC-1002). He held the position of director at Esperion Therapeutics, which developed the first generation of HDL mimetics (pro-apoA-I, apoA-IMilano, and apoA-I peptide) until its acquisition by Pfizer for USD1.3 billion. Before joining Esperion, he was Director of Research for the French pharmaceutical company Fournier, where he established and managed its research center in Heidelberg, Germany. Jean-Louis Dasseux holds an MBA from the Ross School of Business of the University of Michigan, in the United States. He obtained his Master's in biochemistry at the University of Bordeaux II and his PhD in physical chemistry at the University of Bordeaux I. He has held postdoctoral positions at the Department of Chemistry of the University of Laval in Quebec, the Department of Physics at the University of Tennessee in Knoxville, Tennessee, and in the European Molecular Biology Laboratory at Heidelberg in Germany.

Renée Benghozi, MD

Chief Medical Officer

Dr. Renée Benghozi is an international clinical specialist who has over 30 years of experience in the clinical development of molecules in the cardiovascular and diabetes fields. She is a cardiologist and graduate of the Université Paris XII. Since earning her degrees, she has been practicing cardiology at the Hospital Henri Mondor (Créteil) and in parallel in 1982, began a career in the pharmaceutical industry (Sanofi and Novartis) She has spent more than fifteen years at F. Hoffmann-La Roche Ltd. where she was recently the International Medical Director. Her past career in clinical medicine and her substantial experience in the pharmaceutical industry with the cardiology patients are also extremely valuable regarding her critical management role in drug development at Cerenis.

Constance Keyserling, M.S.

Sr. Vice President, Clinical Development

Ms. Keyserling has over 25 years of global clinical development experience at Parke-Davis, Pfizer, Esperion, and QuatRx. She was previously Vice president of Development Operations at QuatRx. Prior to that, Ms. Keyserling was senior director of operations at Esperion, where her responsibilities included clinical program design and management, clinical outsourcing, regulatory operations and SOP systems development. Constance Keyserling holds a Master's degree in biostatistics from Harvard University.

Cyrille Tupin, C.P.A.

Administrative and financial director

Mr. Tupin was previously Audit Director of Sygnatures, the largest private audit and consulting company in Toulouse, France. He spent more than seven years at PriceWaterhouseCoopers with 2 years of international experience in Canada. He has worked on a number of high-profile business transactions, including the Alcan Group takeover bid for Pechiney and the consolidation audit of Pechiney for Alcan. Mr. Tupin has been a French CPA since 2002.

Ronald Barbaras, Ph.D.

Director of Exploratory Biology

With a PhD in biochemistry, Ronald Barbaras has over 30 years of experience in lipid metabolism, the interactions between HDL and cardiovascular disease, including the binding of lipoproteins and the synthesis of cholesterol. Ronald Barbaras was formerly research director and group leader for ATP synthase, HDL metabolism and immune modulation at the National Institute of Health and Medical Research (INSERM), the French public research organization dedicated to biological, medical and public health. He has published over 45 papers in international refereed journals.